Intelligent Chemistry for Better Medicines
Decoding nature’s diverse chemistry with AI to build a new generation of precision oral medicines for the complex biology driving chronic inflammatory diseases
1/3
of adults in America live with a chronic inflammatory disease
~97%
are not currently receiving advanced therapies
A brighter future for patients with chronic inflammatory disease
Our understanding of human biology has grown exponentially, offering new insights into disease and ways to intervene. Yet many of today’s innovative therapies remain out of reach or insufficient for the people who need them. What’s more, many validated biological pathways driving chronic inflammatory diseases have been considered undruggable with small molecules. Montai exists to change this. Our AI-powered engine gives drug developers systematic access to a vastly larger, more diverse chemical universe, uncovering breakthroughs to transform the impossible into accessible oral medicines.
Moving beyond biologics to oral solutions to transform patient access
Designed from the beginning with the patient in mind, our programs aim to deliver potent, selective, and ultimately safer therapies appropriate for long-term use in some of the most prevalent chronic inflammatory diseases.
3B+
library of compounds from diverse untapped scaffolds
9X
hit rate vs. leading public ML models in our diverse chemical space
Purpose built AI to discover oral therapies for hard-to-drug biology
Over 25 clinically validated I&I pathways still have no oral options because this complex biology has lacked binding pockets for small molecules. Montai’s CONECTA platform is built to solve this systematically, by using a biology-first, mechanism-agnostic approach to efficiently explore vast, diverse, and high-value chemistry. This allows us to find novel solutions for hard to drug biology and advance multiple distinct drug candidates at once – on average 24 months from hit to candidate – improving our options and odds of success in the clinic.
An elite expedition team built for the future of medicine
The Montai team comprises experts across human biology, immunology, chemistry, computational biology, data science, machine learning, and drug development. Together, we are climbing mountains to solve unmet patient needs.
